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Brand Name: Proleukin Trade Name: Aldesleukin
FDA Approved For: Adults with metastatic renal cell carcinoma (metastatic RCC). PROLEUKIN is indicated for the treatment of adults with metastatic melanoma. Pediatric Use:
Carcinogen: Mutagen:
Manufacturer and/or Distributor: Chiron Corp    

Adverse Reactions:
The rate of drug-related deaths in the 255 metastatic RCC patients who received single-agent PROLEUKIN (aldesleukin) was 4% (11/255); the rate of drug-related deaths in the 270 metastatic melanoma patients who received single-agent PROLEUKIN was 2% (6/270) The following life-threatening (grade 4) events were reported by <1% of the 525 patients: hypothermia; shock; bradycardia; ventricular extrasystoles; myocardial ischemia; syncope; hemorrhage; atrial arrhythmia; phlebitis; AV block second degree; endocarditis; pericardial effusion; peripheral gangrene; thrombosis; coronary artery disorder; stomatitis; nausea and vomiting; liver function tests abnormal; gastrointestinal hemorrhage; hematemesis; bloody diarrhea; gastrointestinal disorder; intestinal perforation; pancreatitis; anemia; leukopenia; leukocytosis; hypocalcemia; alkaline phosphatase increase; BUN increase; hyperuricemia; NPN increase; respiratory acidosis; somnolence;


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