Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results

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Brain Cancer treatment details. Chemotherapy. Mayo Clinic, Rochester, MN, United States

Survival: 5.7 months
Toxicity Grade: 4
Treatments: Chemotherapy
Country: United States
City/State/Province: Rochester, MN
Hospital: Mayo Clinic
Journal: Link
Date: 4/2009

This phase 2 trial involved 66 patients with recurrent glioblastoma multiforme (GBM). Of these, 29 were female, and 37 were male. Age range of patients was 26-78 years old, with a median age of 58.

Patients were treated with the chemotherapeutic drug,vorinostat, which blocks the growth of cancer cells by inhibiting enzymes called histone deacetylases.

The maximum toxicity grade observed in any of the patients in this study was 4. Grade 3 to 4 hematologic toxicity, including thrombocytopenia, neutropenia, and anemia, was observed in 26% of patients. Nonhematologic toxicities of grade 3 to 4, including fatigue, dehydration, and hypernatremia, were observed in 26% of patients.

Median overall survival in this study was 5.7 months, with a range of 0.7 to 28+ months. The percentage of patients who were progression free at 6 months was 15.2% (10 out of 66 patients).

Some of the authors are employed by the drug manufacturer, Merck & Co.

Correspondence: Dr. Evanthia Galanis; e-mail:

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