Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results
Cancer
 

Click here to go back to your search results.

Brain Cancer treatment details. Biologic therapy. Chemotherapy. Duke University Medical Center, Durham, NC, United States



Survival: 11.9 months
   
Toxicity Grade: 3
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs: Gliadel Wafer
Country: United States
   
City/State/Province: Durham, NC
   
Hospital: Duke University Medical Center
   
Journal: Link
   
Date: 2/2009

Description:
Patients:
This phase 2 trial involved 52 patients with recurrent glioblastoma multiforme, 30 males and 22 females. Patient age ranged from 25 to 69, with a median of 51.5.

Treatment:
Patients were given a chemotherapeutic drug, Gliadel (generic name carmustine), which blocks DNA replication and growth of cancer cells. Wafers of this drug were implanted at the tumor site during surgery. In addition, a biologic agent called O6-benzylguanine was administered after surgery. This drug blocks a DNA repair protein in cells that might be involved in tumor resistance to drugs like Gliadel.

Toxicity:
The highest toxicity level observed in patients was Grade 3, most commonly in the form of brain or cerebrospinal fluid leak (in 19.2% of patients) or infection (in 13.4%). Hydrocephalus, also known as “water on the brain”, was also observed in 9.6% of patients.

Results:
The median overall survival in this study was 11.9 months.

Support:
This study was funded in part by MGI Pharma, the makers of the Gliadel drug.

Correspondence: Dr. Henry Friedman

E-mail to a Friend Email Physician More Information