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Melanoma treatment details. Biologic therapy. Chemotherapy. Mayo Clinic, Rochester, MN, United States



Survival: 12.0 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Rochester, MN
   
Hospital: Mayo Clinic
   
Journal: Link
   
Date: 1/2009

Description:
Patients:
This phase II trial involved 53 patients with metastatic melanoma. Of these, 62.3% were male and the median age was 55 years old (range 30-84).

Treatments:
Patients in this study were administered the chemotherapy agents carboplatin and paclitaxel, as well as a biologic therapy drug called bevacizumab, which is an antibody that blocks a protein involved in cancer cell growth.

Toxicity:
During this study, one patient died from an undiagnosed brain metastases. It was described as "one case of grade 5 central nervous system
hemorrhage." The most common severe toxicities were neutropenia, leucopenia, and anemia. The percentages that experienced Grade 3 or higher level of these toxicities are 53%, 38%, and 8%, respectively.

Results:
The median overall survival in this study was 12 months.

Correspondence: Dr. Svetomir N. Markovic, e-mail: markovic.svetomir@mayo.edu

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