Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results

Click here to go back to your search results.

Melanoma treatment details. Biologic therapy. Chemotherapy. Mayo Clinic, Rochester, MN, United States

Survival: 12.0 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Rochester, MN
Hospital: Mayo Clinic
Journal: Link
Date: 1/2009

This phase II trial involved 53 patients with metastatic melanoma. Of these, 62.3% were male and the median age was 55 years old (range 30-84).

Patients in this study were administered the chemotherapy agents carboplatin and paclitaxel, as well as a biologic therapy drug called bevacizumab, which is an antibody that blocks a protein involved in cancer cell growth.

During this study, one patient died from an undiagnosed brain metastases. It was described as "one case of grade 5 central nervous system
hemorrhage." The most common severe toxicities were neutropenia, leucopenia, and anemia. The percentages that experienced Grade 3 or higher level of these toxicities are 53%, 38%, and 8%, respectively.

The median overall survival in this study was 12 months.

Correspondence: Dr. Svetomir N. Markovic, e-mail:

E-mail to a Friend Email Physician More Information