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Brain Cancer treatment details. Biologic therapy. Chemotherapy. Clinical Center of the National Institutes of Health, Bethesda,MD, United States

Survival: 7.1 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: Bethesda,MD
Hospital: Clinical Center of the National Institutes of Health
Journal: Link
Date: 2/2009

This phase II trial involved 48 recurrent glioblastoma patients, 28 (58%) of whom were male. The median age of the group was 53 years, with a range of 21-69.

Patients were administered the biologic therapy bevacizumab, followed by the chemotherapy drug irinotecan.

The highest toxicity grade reported was grade 4, which was for thromboembolic events including pulmonary embolism. Grade 3 hypertension (2 patients), liver problems (1 patient), and bowel perforation (1 patient) was also reported.

Median overall survival in this study was 7.1 months.

Correspondence: Dr. Howard A. Fine; email:

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