Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results
Cancer
 

Click here to go back to your search results.

Breast Cancer treatment details. Chemotherapy. PUCRS School of Medicine, Porto Alegre, Brazil



Survival: 24.6 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs:
Country: Brazil
   
City/State/Province: Porto Alegre
   
Hospital: PUCRS School of Medicine
   
Journal: Link
   
Date: 3/2010

Description:
Patients:
This phase III trial involved women with HER2-negative advanced breast cancer that recurred following treatment with anthracycline and taxane. The study was divided into two groups - "Arm A" and "Arm B." Arm A of the study consisted of 238 patients with a median age of 53 years (range 25-80). There were 244 patients in arm B and the median age was also 53 (range 23-80).

Treatment:
Patients in arm A were treated with sunitinib, which is a biological agent ( multi-targeted receptor tyrosine kinase (RTK) inhibitor) which targets angiogenesis (new blood vessel formation). Patients in arm B were treated with the chemotherapy agent capecitabine, which blocks cancer cell division (growth).

Toxicities:
Seven patients (5 in arm A, 2 in arm B) died due to treatment-related adverse events including kidney and liver failure, cerebral hemorrhage, and pulmonary embolism. The most commonly reported toxicities overall in this study were diarrhea, hand-foot syndrome (reddening of the hands and feet), and nausea.

Results:
For arm A of this study, the median overall survival was 15.3 months and the median progression-free survival was 2.8 months. For arm B, the median overall survival was 24.6 months and the median progression-free survival was 4.2 months.

Support:
This study was funded by Pfizer Inc., makers of Sutent (trade name for sunitinib).

Correspondence: Dr. C. H. Barrios; email: chbe@via-rs.net

E-mail to a Friend Email Physician More Information