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Breast Cancer treatment details. Chemotherapy. PUCRS School of Medicine, Porto Alegre, Brazil

Survival: 24.6 months
Toxicity Grade: 5
Treatments: Chemotherapy
Country: Brazil
City/State/Province: Porto Alegre
Hospital: PUCRS School of Medicine
Journal: Link
Date: 3/2010

This phase III trial involved women with HER2-negative advanced breast cancer that recurred following treatment with anthracycline and taxane. The study was divided into two groups - "Arm A" and "Arm B." Arm A of the study consisted of 238 patients with a median age of 53 years (range 25-80). There were 244 patients in arm B and the median age was also 53 (range 23-80).

Patients in arm A were treated with sunitinib, which is a biological agent ( multi-targeted receptor tyrosine kinase (RTK) inhibitor) which targets angiogenesis (new blood vessel formation). Patients in arm B were treated with the chemotherapy agent capecitabine, which blocks cancer cell division (growth).

Seven patients (5 in arm A, 2 in arm B) died due to treatment-related adverse events including kidney and liver failure, cerebral hemorrhage, and pulmonary embolism. The most commonly reported toxicities overall in this study were diarrhea, hand-foot syndrome (reddening of the hands and feet), and nausea.

For arm A of this study, the median overall survival was 15.3 months and the median progression-free survival was 2.8 months. For arm B, the median overall survival was 24.6 months and the median progression-free survival was 4.2 months.

This study was funded by Pfizer Inc., makers of Sutent (trade name for sunitinib).

Correspondence: Dr. C. H. Barrios; email:

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