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Liver Cancer treatment details. Biologic therapy. Queen Mary Hospital, Hong Kong, China



Survival: 5.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: China
   
City/State/Province: Hong Kong
   
Hospital: Queen Mary Hospital
   
Journal: Link
   
Date: 1/2009

Description:
Patients:
This Phase 2 study involved 51 patients with hepatocellular carcinoma. Of these, 88% were male and the median age was 56 years with a range of 28-79.

Treatment:
Patients were administered the biological agent sorafenib. Sorafenib is a small molecular inhibitor of several Tyrosine protein kinases.

Toxicities:
The maximum level of toxicity reported was grade 4 (anemia and liver biochemistry effects). Other side effects included thrombocytopenia, diarrhea, and hand-foot skin reaction (redness of hands and feet, also known as hand-foot syndrome).

Results:
The median overall survival was 5 months with a range of 3-17 months. Overall median progression-free survival was 3 months with a range of 3-17 months.

Correspondence: Dr. Ronnie T. Poon; email: poontp@hkumL.hku.hk

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