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Liver Cancer treatment details. Biologic therapy. Queen Mary Hospital, Hong Kong, China

Survival: 5.0 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: China
City/State/Province: Hong Kong
Hospital: Queen Mary Hospital
Journal: Link
Date: 1/2009

This Phase 2 study involved 51 patients with hepatocellular carcinoma. Of these, 88% were male and the median age was 56 years with a range of 28-79.

Patients were administered the biological agent sorafenib. Sorafenib is a small molecular inhibitor of several Tyrosine protein kinases.

The maximum level of toxicity reported was grade 4 (anemia and liver biochemistry effects). Other side effects included thrombocytopenia, diarrhea, and hand-foot skin reaction (redness of hands and feet, also known as hand-foot syndrome).

The median overall survival was 5 months with a range of 3-17 months. Overall median progression-free survival was 3 months with a range of 3-17 months.

Correspondence: Dr. Ronnie T. Poon; email:

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