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Mesothelioma Cancer treatment details. Chemotherapy. Cleveland Clinic Foundation, Cleveland, OH, United States



Survival: 10.0 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Cleveland, OH
   
Hospital: Cleveland Clinic Foundation
   
Journal: Link
   
Date: 5/2008

Description:
Patients:
This study involved 50 patients with unresectable malignant pleural mesothelioma. The median age was 69 (range of 36-80) and 88% were male. Patients had not received any prior chemotherapy or radiation.

Treatment:
Patients were administered a combination of the chemotherapy drugs cisplatin and gemcitabine (trade name Gemzar).

Toxicities:
The highest toxicity grade reported was grade 4. Some of the most common grade 3 or 4 toxicities were neutropenia (50% of patients), thrombocytopenia (32%), and fatigue (24%).

Results:
The median overall survival for this study was 10 months, with a range of 7-15 months.

Support:
This study was partially supported by Eli Lilly and Company, the makers of Gemzar (trade name for gemcitabine).

Correspondence: Dr. Sujith R. Kalmadi; email: kalmads@ccf.org

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