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Prostate Cancer treatment details. Chemotherapy. The Cancer Institute of New Jersey, UMDNJ-RWJMS, New Brunswick NJ, United States

Survival: 19.4 months
Toxicity Grade: 4
Treatments: Chemotherapy
Country: United States
City/State/Province: New Brunswick NJ
Hospital: The Cancer Institute of New Jersey, UMDNJ-RWJMS
Journal: Link
Date: 2/2010

This phase II trial involved 63 men with metastatic castration-resistant prostate cancer that were separated into 2 separate studies (arms). Arm A involved 32 of the men with a median age of 70 years (range 50-89). Arm B involved 31 men with a median age of 65 years (range 45-80).

Patients in Arm A were treated with a combination of the chemotherapy agents mitoxantrone, estramustine and vinorelbine.

Patients in Arm B received a combination of the biologic therapies 13-cis retinoic acid and interferon-alpha 2b, and the chemotherapy agent paclitaxel.

The highest toxicity level reported for this study was grade 4, mostly in the form of neutropenia. Other toxicities included leucopenia and fatigue.

Median overall survival was 19.4 months for Arm A and 13.9 months for Arm B.

Correspondence: Dr. Robert S. DiPaola; email:

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