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Brain Cancer treatment details. Chemotherapy. Radiation. Emory University, Atlanta, Georgia, United States



Survival: 9.3 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
Radiation
   
Drugs: BCNU, BiCNU
Platinol
Country: United States
   
City/State/Province: Atlanta, Georgia
   
Hospital: Emory University
   
Journal: Link
   
Date: 4/2000

Description:
Patients: This Phase II study involved 47 patients with newly diagnosed glioblastoma multiforme.

Treatment: Treatment consisted of the administration of two chemotherapy drugs, BCNU and cisplatin followed by radiotherapy.

Toxicity: Two patients died while undergoing treatment and their deaths were thought to be possibly treatment-related. In respect to chemotherapy, toxicities included: leucopenia (grade 3-4), granulocytopenia (grade 3-4), thrombocytopenia (grade 3-4), anemia (grade 3-4), infection (grade 3-4), nausea (grade 3), vomiting (grade 3), liver (grade 3), cardiac (grade 4), pulmonary (grade 4), phlebitis (DVT or PE) (grade 3-4), neurologic worsening (grade 3-4), metabolic (grade 3), and coagulation (grade 3).

Results: Median survival was 9.3 months.

Correspondence: Mark Gilbert, MD

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