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Prostate Cancer treatment details. Biologic therapy. Chemotherapy. The Cancer Institute of New Jersey, UMDNJ-RWJMS, New Brunswick NJ, United States



Survival: 13.9 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: New Brunswick NJ
   
Hospital: The Cancer Institute of New Jersey, UMDNJ-RWJMS
   
Journal: Link
   
Date: 2/2010

Description:
Patients:
This phase II trial involved 63 men with metastatic castration-resistant prostate cancer that were separated into 2 separate studies (arms). Arm A involved 32 of the men with a median age of 70 years (range 50-89). Arm B involved 31 men with a median age of 65 years (range 45-80).

Treatment:
Patients in Arm A were treated with a combination of the chemotherapy agents mitoxantrone, estramustine and vinorelbine.

Patients in Arm B received a combination of the biologic therapies 13-cis retinoic acid and interferon-alpha 2b, and the chemotherapy agent paclitaxel.

Toxicities:
The highest toxicity level reported for this study was grade 4, mostly in the form of neutropenia. Other toxicities included leucopenia and fatigue.

Results:
Median overall survival was 19.4 months for Arm A and 13.9 months for Arm B.

Correspondence: Dr. Robert S. DiPaola; email: dipaolrs@umdnj.edu

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