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Rectal Cancer treatment details. Biologic therapy. Chemotherapy. Hôpital Ambroise Paré, Boulogne Cedex, France



Survival: 22.4 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: France
   
City/State/Province: Boulogne Cedex
   
Hospital: Hôpital Ambroise Paré
   
Journal: Link
   
Date: 4/2009

Description:
Patients:
This study involved 52 patients with EGFR-detectable metastatic colorectal cancer. The median age of the patients was 61 years, and 63.5% were male.

Treatment:
Patients were treated with a biologic therapy cetuximab, which is a monoclonal antibody that targets the epidermal growth factor receptor protein on cancer cells and inhibits cell growth. In addition, patients were given a combination of the chemotherapy agents irinotecan, 5-fluorouracil, and folinic acid (this combination is sometimes referred to as FOLFIRI).

Toxicities:
Grade 3 or 4 toxicities were reported for 65% of the patients, including leucopenia, rash, diarrhea, vomiting, and weakness.

Results:
The median overall survival was 22.4 months. The median progression-free survival was 7.9 months.

Support:
This study was partially supported by Merck KGaA, the makers of cetuximab (trade name Erbitux).

Correspondence: Dr. Philippe Rougier; email: rougier.philippe@wanadoo.fr

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