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Lung Cancer treatment details. Chemotherapy. National Cancer Center, Singapore, Singapore

Survival: 9.9 months
Toxicity Grade: 5
Treatments: Chemotherapy
Country: Singapore
City/State/Province: Singapore
Hospital: National Cancer Center
Journal: Link
Date: 7/2010

This was a “2-arm” study in which patients with advanced non-small-cell lung cancer were separated into two treatment groups, called arm A and arm B. Arm A consisted of 190 patients with a median age of 59.4 years and 73.2% male. In arm B, there were 191 patients with a median age of 62.1 years and 76.4% male.

Patients in arm A received the chemotherapy agents cisplatin and vinorelbine (intravenously and orally), which block cancer cell division (growth).

Patients in arm B were given cisplatin and docetaxel, which is also a chemotherapy agent that blocks cancer cell division.

In arm A, there was one death due to neutropenia reported. Three deaths were reported for arm B due to gastrointestinal perforation, septic shock, and peritoneal infection. Other grade 3 and 4 toxicities reported for both groups included leucopenia and vomiting.

Median overall survival in arm A of the study was 9.9 months. For arm B, the median overall survival was 9.8 months.

This study was supported by Pierre Fabre Pharma, the makers of oral vinorelbine (trade name Navelbine).

Correspondence: Dr. E.H. Tan; email:

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