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Lung Cancer treatment details. Chemotherapy. National Cancer Center, Singapore, Singapore



Survival: 9.9 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs:
Country: Singapore
   
City/State/Province: Singapore
   
Hospital: National Cancer Center
   
Journal: Link
   
Date: 7/2010

Description:
Patients:
This was a “2-arm” study in which patients with advanced non-small-cell lung cancer were separated into two treatment groups, called arm A and arm B. Arm A consisted of 190 patients with a median age of 59.4 years and 73.2% male. In arm B, there were 191 patients with a median age of 62.1 years and 76.4% male.

Treatment:
Patients in arm A received the chemotherapy agents cisplatin and vinorelbine (intravenously and orally), which block cancer cell division (growth).

Patients in arm B were given cisplatin and docetaxel, which is also a chemotherapy agent that blocks cancer cell division.

Toxicities:
In arm A, there was one death due to neutropenia reported. Three deaths were reported for arm B due to gastrointestinal perforation, septic shock, and peritoneal infection. Other grade 3 and 4 toxicities reported for both groups included leucopenia and vomiting.

Results:
Median overall survival in arm A of the study was 9.9 months. For arm B, the median overall survival was 9.8 months.

Support:
This study was supported by Pierre Fabre Pharma, the makers of oral vinorelbine (trade name Navelbine).

Correspondence: Dr. E.H. Tan; email: tanenghuat123@gmail.com

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