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Melanoma treatment details. Chemotherapy. Moffitt Cancer Center, Tampa, FL, United States



Survival: 7.5 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Tampa, FL
   
Hospital: Moffitt Cancer Center
   
Journal: Link
   
Date: 4/2009

Description:
Patients:
This study involved 39 melanoma patients. The median age was 61 years (range 29-89) and 74% were male.

Treatment:
Patients were given two chemotherapy agents, karenitecin (a topoisomerase inhibitor) and valproic acid (a histone deacetylase inhibitor), which cause DNA damage and cancer cell death.

Toxicities:
The highest toxicity grade reported was grade 4, due to low neutrophil count (4 patients) and low hemoglobin levels (3). Grade 3 neurological toxicities were also reported (confusion in 2 patients and drowsiness in 1 patient).

Results:
The median overall survival for this study was 7.5 months.

Support:
One of the authors of this study works for BioNumerik, the supplier of karenitecin.

Correspondence: Dr. Adil Daud; email: adaud@medicine.ucsf.edu

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