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Mesothelioma Cancer treatment details. Biologic therapy. Istituto Clinico Humanitas,, Rozzano, Italy

Survival: 12.1 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: Italy
City/State/Province: Rozzano
Hospital: Istituto Clinico Humanitas,
Journal: Link
Date: 5/2010

This study involved 43 patients with malignant pleural mesothelioma. The median age was 64 years and 63% were male.

Patients in this study were given asparagine-glycine-arginine-human tumor necrosis factor alpha (NGR-hTNF), which is a biologic therapy agent that targets tumor blood vessels to cause tumor cell death.

The highest report toxicity level in this study was grade 4, including shortness of breath, respiratory failure, and fatigue. The most common adverse events of any grade were chills (71% of patients; grade 1-2), pain (49%; grade 1-3), and fatigue (37%; grade 1-4).

The median overall survival in this study was 12.1 months.

This study was supported by MolMed, the makers of NGR-hTNF.

Correspondence: Dr. Claudio Bordignon; email:

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