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Brain Cancer treatment details. Biologic therapy. Chemotherapy. Radiation. Sarah Cannon Research Institute, Nashville, TN, United States



Survival: 12.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
Radiation
   
Drugs:
Country: United States
   
City/State/Province: Nashville, TN
   
Hospital: Sarah Cannon Research Institute
   
Journal: Link
   
Date: 8/2010

Description:
Patients:
This study involved 47 patients with glioblastoma multiforme. The median age was 54 years (range of 28-79) and 66% were male.

Treatment:
Patients in this study received radiotherapy, the chemotherapy agent temozolomide, and a biological therapy agent called sorafenib, which is a tyrosine kinase inhibitor.

Toxicities:
The highest toxicity grade reported was grade 4, consisting of one case of thrombocytopenia and one case of pulmonary embolus. Grade 3 toxicities (in 5 patients) included skin reactions (hand-foot skin reaction and rash) and fatigue.

Results:
Median overall survival in this study was 12 months. Median progression-free survival was 6 months.

Support:
This study was partially funded by Bayer-Onyx, makers of Nexavar (trade name for sorafenib).

Correspondence: Dr. John D. Hainsworth; email: jhainsworth@tnonc.com

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