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Liver Cancer treatment details. Biologic therapy. Mayo Clinic Florida, Jacksonville, FL, United States



Survival: 6.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Jacksonville, FL
   
Hospital: Mayo Clinic Florida
   
Journal: Link
   
Date: 9/2010

Description:
Patients:
This phase II study involved 35 patients with surgically unresectable or metastatic hepatocellular carcinoma. The median age was 61 years and 80% of the patients were male.

Treatment:
Patients were treated with a biologic therapy bortezomib, which is a proteosome inhibitor. This drug blocks protein production in cancer cells, which can lead to cell death.

Toxicities:
The maximum toxicity level reported in this study was grade 4 and included thrombosis (2 cases), hepatic failure (1) and hypoglycemia (1).

Results:
The median overall survival in this study was 6.0 months.

Correspondence: Dr. George P. Kim; email:kim.george@mayo.edu

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