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Liver Cancer treatment details. Biologic therapy. Mayo Clinic Florida, Jacksonville, FL, United States

Survival: 6.0 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: Jacksonville, FL
Hospital: Mayo Clinic Florida
Journal: Link
Date: 9/2010

This phase II study involved 35 patients with surgically unresectable or metastatic hepatocellular carcinoma. The median age was 61 years and 80% of the patients were male.

Patients were treated with a biologic therapy bortezomib, which is a proteosome inhibitor. This drug blocks protein production in cancer cells, which can lead to cell death.

The maximum toxicity level reported in this study was grade 4 and included thrombosis (2 cases), hepatic failure (1) and hypoglycemia (1).

The median overall survival in this study was 6.0 months.

Correspondence: Dr. George P. Kim;

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