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Lung Cancer treatment details. Biologic therapy. Chemotherapy. Radiation. Vanderbilt University Medical Center, Nashville, TN, United States



Survival: 6.7 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
Radiation
   
Drugs:
Country: United States
   
City/State/Province: Nashville, TN
   
Hospital: Vanderbilt University Medical Center
   
Journal: Link
   
Date: 3/2009

Description:
Patients:
This phase II study involved 17 patients with stage III non-small cell lung cancer. Patients had not received previous treatment. The median patient age was 58 years, and 13 of the patients were male.

Treatment:
Patients received radiation therapy in combination with the chemotherapy agents paclitaxel and carboplatin and the biologic therapy agent celecoxib (brand name: Celebrex), which is a COX-2 inhibitor that inhibits tumor cell growth.

Toxicities:
There were two deaths (grade 5 toxicity) reported in this study due to respiratory failure and pulmonary embolism. Other toxicities of grade 3 and 4 included neutropenia, hyperglycemia, and pneumonia.

Results:
The median overall survival in this study was 6.7 months. Median progression-free survival was 4.5 months.

Correspondence: Dr. Bo Lu; email: bo.lu@vanderbilt.edu

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