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Lung Cancer treatment details. Biologic therapy. Chemotherapy. Radiation. Vanderbilt University Medical Center, Nashville, TN, United States

Survival: 6.7 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Nashville, TN
Hospital: Vanderbilt University Medical Center
Journal: Link
Date: 3/2009

This phase II study involved 17 patients with stage III non-small cell lung cancer. Patients had not received previous treatment. The median patient age was 58 years, and 13 of the patients were male.

Patients received radiation therapy in combination with the chemotherapy agents paclitaxel and carboplatin and the biologic therapy agent celecoxib (brand name: Celebrex), which is a COX-2 inhibitor that inhibits tumor cell growth.

There were two deaths (grade 5 toxicity) reported in this study due to respiratory failure and pulmonary embolism. Other toxicities of grade 3 and 4 included neutropenia, hyperglycemia, and pneumonia.

The median overall survival in this study was 6.7 months. Median progression-free survival was 4.5 months.

Correspondence: Dr. Bo Lu; email:

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