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Liver Cancer treatment details. Biologic therapy. Chemotherapy. Queen Mary Hospital, Hong Kong, China



Survival: 7.3 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: China
   
City/State/Province: Hong Kong
   
Hospital: Queen Mary Hospital
   
Journal: Link
   
Date: 11/2010

Description:
Patients:
This study involved 27 patients with advanced hepatocellular carcinoma. The median age was 52 years and 92.6% were male.

Treatment:
Patients in this study were given a combination of a biologic therapy called PTK787/ZK222584, or PTK and the chemotherapy agent doxorubicin. PTK targets tyrosine kinase and VEGF receptor proteins in cancer cells, which leads to cell death. Another name for PTK is vatalanib.

Toxicities:
Two deaths due to hemorrhagic complications were reported in this study. Other reported toxicities included nausea, alopecia, and mucositis (inflammation of the stomach and mouth).

Results:
The median progression free survival was 5.4 months. Median overall survival was 7.3 months.

Support:
This study was partially supported by Novartis, makers of vatalanib.

Correspondence: Dr. Ronnie T. Poon; email: poontp@hkumL.hku.hk

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