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Liver Cancer treatment details. Biologic therapy. Chemotherapy. Queen Mary Hospital, Hong Kong, China

Survival: 7.3 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: China
City/State/Province: Hong Kong
Hospital: Queen Mary Hospital
Journal: Link
Date: 11/2010

This study involved 27 patients with advanced hepatocellular carcinoma. The median age was 52 years and 92.6% were male.

Patients in this study were given a combination of a biologic therapy called PTK787/ZK222584, or PTK and the chemotherapy agent doxorubicin. PTK targets tyrosine kinase and VEGF receptor proteins in cancer cells, which leads to cell death. Another name for PTK is vatalanib.

Two deaths due to hemorrhagic complications were reported in this study. Other reported toxicities included nausea, alopecia, and mucositis (inflammation of the stomach and mouth).

The median progression free survival was 5.4 months. Median overall survival was 7.3 months.

This study was partially supported by Novartis, makers of vatalanib.

Correspondence: Dr. Ronnie T. Poon; email:

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