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Rectal Cancer treatment details. Biologic therapy. Chemotherapy. Campus Bio-Medico University, Rome, Italy

Survival: 7.7 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: Italy
City/State/Province: Rome
Hospital: Campus Bio-Medico University
Journal: Link
Date: 10/2010

This study involved 48 patients with advanced colorectal cancer whose cancer had progressed following previous standard chemotherapy approaches. The median patient age was 68 (range 31-74) and 47.2% were men.

Patients were treated with a combination of the chemotherapy agent 5-FU/folinic acid and the biologic therapy agent bevacizumab, which is an antibody that blocks a protein involved in cancer cell growth.

The maximum toxicity level reported was of grade 4. Grade 3 or 4 adverse events included neutropenia (12.5% of patients), diarrhea (20.8%), hypertension (12.5%), and hemorrhaging of the gastrointestinal tract (8.3%) or nose (6.2%).

The median overall survival in this study was 7.7 months.

Correspondence: Dr. Antonio Russo

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