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Liver Cancer treatment details. Biologic therapy. Istituto Clinico Humanitas, Rozzano, Italy

Survival: 8.9 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: Italy
City/State/Province: Rozzano
Hospital: Istituto Clinico Humanitas
Journal: Link
Date: 9/2010

This study involved 27 patients with advanced hepatocellular carcinoma. The median age of the group was 67 years and 82% were male.

Patients in this study were administered the biologic therapy NGR-hTNF, which has antivascular activity (limits blood supply to tumors).

The highest toxicity grade reported in this study was grade 4 and included anemia, liver failure, and pulmonary embolism. The most common adverse events of any grade were chills (63%), pain (33%), and weakness (30%).

The reported median overall survival was 8.9 months.

Correspondence: Dr. Claudio Bordignon; email:

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