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Ovarian Cancer treatment details. Chemotherapy. Vancouver Clinic, Vancouver, BC, Canada

Survival: 42.1 months
Toxicity Grade: 5
Treatments: Chemotherapy
Country: Canada
City/State/Province: Vancouver, BC
Hospital: Vancouver Clinic
Journal: Link
Date: 10/2010

This phase 3 trial involved women with newly diagnosed ovarian cancer who had not received previous chemotherapy. Patients were divided into two treatment groups. Group 1 consisted of 409 patients with a median age of 57 years and group 2 had 410 patients with a median age of 57 years.

Patients in group 1 were given a combination of four chemotherapy agents: cisplatin, topotecan, paclitaxel, and carboplatin.

Patients in group 2 were given the chemotherapy agents paclitaxel and carboplatin.

Two deaths due to sepsis (systemic inflammation) were reported for group 1. Also reported was grade 4 granulocytopenia (85% of patients).

Two deaths due to sepsis were also reported for group 2. Neurosensory effects were also reported in 84% of patients.

The median overall survival in group 1 was 42.3 months.

For group 2, the median overall survival was 42.1 months.

This study was partially supported by the pharmaceutical company Glaxo SmithKline.

Correspondence: Dr. Paul Hoskins; email:

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