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Brain Cancer treatment details. Chemotherapy. Duke University Medical Center, Durham, North Carolina, United States



Survival: 11.9 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: BCNU, BiCNU
Camptosar
Country: United States
   
City/State/Province: Durham, North Carolina
   
Hospital: Duke University Medical Center
   
Journal: Link
   
Date: 4/2004

Description:
Patients: This Phase II study involved 56 patients with glioblastoma multiforme, 18 with anaplastic astrocytoma, and 2 with anaplastic oligodendroglioma. Patients were either newly diagnosed or had recurrent tumors.

Treatment: Treatment consisted of two chemotherapy drugs, irinotecan (camptosar) plus BCNU.

Toxicity: There were five deaths associated with this treatment: four fatal infections and a death from pulmonary failure. Other toxicities included: thrombocytopenia, neutropenia, dairhhea/dehydration, thrombosis, transaminase, and ileus.

Results: Median overall survival for the newly diagnosed glioblastoma patients was 51.3 weeks (11.9 months).

Correspondence: David A. Reardon, MD

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