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Lung Cancer treatment details. Biologic therapy. Chemotherapy. Princess Margaret Hospital, Toronto, ON, Canada

Survival: 7.9 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: Canada
City/State/Province: Toronto, ON
Hospital: Princess Margaret Hospital
Journal: Link
Date: 9/2009

This phase 2 study involved 18 patients with non-small-cell lung cancer (NSCLC) who had received prior chemotherapy. The median age of the group was 53 years and 50% of the patients were male.

Patients in this study were given a biologic therapy agent called GTI-2040 followed by the chemotherapy agent docetaxel. GTI-2040 is an antisense oligonucleotide, which targets and disrupts DNA synthesis, thus preventing cancer cell growth.

The maximum toxicity reported for the patients in the phase 2 study was grade 4. Grade 3-4 toxicities included fatigue, shortness of breath, and low white blood cell and neutrophil counts.

The median overall survival reported for this study was 7.9 months.

Correspondence: Dr. Natasha Leighl; email:

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