Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results
Cancer
 

Click here to go back to your search results.

Lung Cancer treatment details. Biologic therapy. Chemotherapy. Princess Margaret Hospital, Toronto, ON, Canada



Survival: 7.9 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Canada
   
City/State/Province: Toronto, ON
   
Hospital: Princess Margaret Hospital
   
Journal: Link
   
Date: 9/2009

Description:
Patients:
This phase 2 study involved 18 patients with non-small-cell lung cancer (NSCLC) who had received prior chemotherapy. The median age of the group was 53 years and 50% of the patients were male.

Treatment:
Patients in this study were given a biologic therapy agent called GTI-2040 followed by the chemotherapy agent docetaxel. GTI-2040 is an antisense oligonucleotide, which targets and disrupts DNA synthesis, thus preventing cancer cell growth.

Toxicities:
The maximum toxicity reported for the patients in the phase 2 study was grade 4. Grade 3-4 toxicities included fatigue, shortness of breath, and low white blood cell and neutrophil counts.

Results:
The median overall survival reported for this study was 7.9 months.

Correspondence: Dr. Natasha Leighl; email: natasha.leighl@uhn.on.ca

E-mail to a Friend Email Physician More Information