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Liver Cancer treatment details. Biologic therapy. Radiation. National Institute of Cancer Research, Tainan, Taiwan Region



Survival: 7.9 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Radiation
   
Drugs:
Country: Taiwan Region
   
City/State/Province: Tainan
   
Hospital: National Institute of Cancer Research
   
Journal: Link
   
Date: 1/2011

Description:
Patients:
In this study, patients with hepatocellular carcinoma were divided into 2 treatment groups. Group A included 18 patients, 83.3% were male and 72.2% were under the age of 70. In group B, there were 24 patients, 83.3% of whom were male, and 79.2% were under the age of 70.

Treatment:
Group A was treated with radiation alone. Group B was treated with radiation and the biologic agent thalidomide, which inhibits the formation of blood vessels in the tumor, therefore blocking tumor growth.

Toxicities:
The maximum level of toxicity for both groups was grade 4. Grade 3-4 adverse events in group A included infection (reported in 16.7% of patients) and liver dysfunction (38.9%). Grade 3-4 events reported in group B included skin rash (20.8% of patients) and liver dysfunction (37.5%).

Results:
The median progression-free survival for group A was 6.0 months and the median overall survival was 8.5 months. For group B, the median, progression-free survival was 4.9 months and the median overall survival was 7.9 months.

Correspondence: Dr. Hui-Ju Ch’ang; email: hjmc@nhri.org.tw

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