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Liver Cancer treatment details. Biologic therapy. Radiation. National Institute of Cancer Research, Tainan, Taiwan Region

Survival: 7.9 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: Taiwan Region
City/State/Province: Tainan
Hospital: National Institute of Cancer Research
Journal: Link
Date: 1/2011

In this study, patients with hepatocellular carcinoma were divided into 2 treatment groups. Group A included 18 patients, 83.3% were male and 72.2% were under the age of 70. In group B, there were 24 patients, 83.3% of whom were male, and 79.2% were under the age of 70.

Group A was treated with radiation alone. Group B was treated with radiation and the biologic agent thalidomide, which inhibits the formation of blood vessels in the tumor, therefore blocking tumor growth.

The maximum level of toxicity for both groups was grade 4. Grade 3-4 adverse events in group A included infection (reported in 16.7% of patients) and liver dysfunction (38.9%). Grade 3-4 events reported in group B included skin rash (20.8% of patients) and liver dysfunction (37.5%).

The median progression-free survival for group A was 6.0 months and the median overall survival was 8.5 months. For group B, the median, progression-free survival was 4.9 months and the median overall survival was 7.9 months.

Correspondence: Dr. Hui-Ju Ch’ang; email:

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