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Lung Cancer treatment details. Biologic therapy. Chemotherapy. Kantonsspital St.Gallen, St. Gallen, Switzerland



Survival: 11.5 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Switzerland
   
City/State/Province: St. Gallen
   
Hospital: Kantonsspital St.Gallen
   
Journal: Link
   
Date: 4/2008

Description:
Patients:
This study involved 63 non-small-cell lung cancer patients who had not received prior chemotherapy. The median age was 62 years and 62% were male.

Treatment:
Patients were treated with a biologic therapy called gefitinib (an inhibitor of the epidermal growth factor receptor tyrosine kinase) as well as the chemotherapy agents gemcitabine and cisplatin.

Toxicities:
The most severe adverse effects were of grade 4 and included neutropenia and thrombocytopenia. Also reported were grade 3 diarrhea, fatigue, and infection.

Results:
The median overall survival was 11.5 months.

Support:
This study was supported by Astra Zeneca, makers of gefitinib (trade name: Iressa).

Correspondence: Dr. Dr G. D’Addario; email: g.daddario@hin.ch

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