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Brain Cancer treatment details. Chemotherapy. Radiation. Seoul National University Hospital, Seoul, Korea



Survival: 18.9 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Radiation
   
Drugs:
Country: Korea
   
City/State/Province: Seoul
   
Hospital: Seoul National University Hospital
   
Journal: Link
   
Date: 11/2010

Description:
Patients:
In this study, glioblastoma patients were separated into two different treatment groups. Group A consisted of 42 patients with a median age of 51.1 years, 35.7% of whom were male. Group B included 40 patients with a median age of 51.4 years and 27.5% male.

Treatment:
Patients in group A were treated with radiation therapy and the chemotherapy agent temozolomide.
Patients in group B were treated with radiation therapy and the chemotherapy agents nimustine, cisplatin, and temozolomide.

Toxicities:
The most severe adverse events in group A were of grade 3-4 and included 1 case of thrombocytopenia, 2 cases of headache, and 1 case of hemiparesis (weakness on one side of the body).
The most severe adverse events in group B were of grade 5, including death due to sepsis. Also reported were grade 3-4 neutropenia and thrombocytopenia (6 cases each) and grade 3-4 liver toxicity (2 cases).

Results:
The median overall survival for group A was 18.9 months. For group B, median overall survival was 28.4 months.

Correspondence: Dr. Hee-Won Jung; email: hwnjung@snu.ac.kr

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