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Liver Cancer treatment details. Biologic therapy. National Cancer Center, Goyang, Gyeonggi, Korea

Survival: 10.0 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: Korea
City/State/Province: Goyang, Gyeonggi
Hospital: National Cancer Center
Journal: Link
Date: 3/2011

This study consisted of 55 patients with advanced hepatocellular carcinoma. The median patient age was 60 years (range of 27-80) and 89.1% were male.

Patients were treated with the biologic therapy agent brivanib, which inhibits proteins (FGF and VEGF) involved in cancer cell growth.

The maximum reported toxicity level was grade 4, including fatigue (grade 3-4 in 16.4% of patients), hypertension (10.9% with grade 3-4), and diarrhea (3.6% with grade 3-4).

The median progression-free survival for this study was 2.7 months. The median overall survival was 10 months.

This study was supported by Bristol Myers-Squibb, the makers of brivanib.

Correspondence: Dr. Joong-Won Park; email:

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