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Melanoma treatment details. Biologic therapy. The Angeles Clinic and Research Institute, Santa Monica, CA, United States

Survival: 10.2 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Santa Monica, CA
Hospital: The Angeles Clinic and Research Institute
Journal: Link
Date: 8/2010

This study involved 155 melanoma patients who have received prior treatment. The median patient age was 59 years and 52% were male.

Patients in this study were treated with the biologic therapy agent ipilimumab, which is a monoclonal antibody that blocks a protein called CTLA-4 and helps the immune system target cancer cells.

One treatment-related death due to liver failure was reported in this study (toxicity grade 5). Otherwise, the majority of adverse events were immune-related reactions on the skin and in the gastrointestinal tract.

The median overall survival for this study was 10.2 months.

This study was supported by Bristol Myers-Squibb, the makers of ipilimumab.

Correspondence: Dr. S. J. O’Day; email:

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