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Melanoma treatment details. Biologic therapy. The Angeles Clinic and Research Institute, Santa Monica, CA, United States



Survival: 10.2 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Santa Monica, CA
   
Hospital: The Angeles Clinic and Research Institute
   
Journal: Link
   
Date: 8/2010

Description:
Patients:
This study involved 155 melanoma patients who have received prior treatment. The median patient age was 59 years and 52% were male.

Treatment:
Patients in this study were treated with the biologic therapy agent ipilimumab, which is a monoclonal antibody that blocks a protein called CTLA-4 and helps the immune system target cancer cells.

Toxicities:
One treatment-related death due to liver failure was reported in this study (toxicity grade 5). Otherwise, the majority of adverse events were immune-related reactions on the skin and in the gastrointestinal tract.

Results:
The median overall survival for this study was 10.2 months.

Support:
This study was supported by Bristol Myers-Squibb, the makers of ipilimumab.

Correspondence: Dr. S. J. O’Day; email: SODay@theangelesclinic.org

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