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Mesothelioma Cancer treatment details. Chemotherapy. Finsen Centre/National University Hospital, Copenhagen, Denmark



Survival: 8.5 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs: Pemetrexed
Country: Denmark
   
City/State/Province: Copenhagen
   
Hospital: Finsen Centre/National University Hospital
   
Journal: Link
   
Date: 2/2007

Description:
Patients:
This study involved patients with malignant pleural mesothelioma who had previously been treated with platinum-based chemotherapy. Patients were divided into two separate treatment groups. Group A included 28 patients with a median age of 62 years, 93% of whom were male. Group B consisted of 11 patients with a median age of 62 years, 82% of whom were male.

Treatment:
Patients in group A were treated with the chemotherapy agent pemetrexed.
Patients in group B were given a combination of the chemotherapy agents pemetrexed and carboplatin.

Toxicities:
The maximum toxicity level reported for group A was grade 5 due to death from sepsis. Grade 4 leukopenia and thrombocytopenia were also reported.
The maximum toxicity grade reported for group B was grade 4 for leukopenia and thrombocytopenia.

Results:
The median overall survival for group A was 9.7 months.
The median overall survival for group B was 8.5 months.

Correspondence: Dr. Jens Benn Sorensen; email: jbsonk@rh.dk

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