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Ovarian Cancer treatment details. Chemotherapy. Mount Vernon Cancer Centre, Northwood, Middlesex, United Kingdom

Survival: 7.8 months
Toxicity Grade: 4
Treatments: Chemotherapy
Country: United Kingdom
City/State/Province: Northwood, Middlesex
Hospital: Mount Vernon Cancer Centre
Journal: Link
Date: 3/2011

This phase 2 trial involved women with ovarian cancer that had progressed following prior platinum-based chemotherapy. Patients were divided into two treatment groups. Group A consisted of 25 patients with a median age of 62 years. Group B was made up of 38 patients with a median age of 59 years.

Both groups were treated with the chemotherapy agent sagopilone, which stops cancer cells from dividing, but groups were treated using different infusion schedules. Patients in group A were administered sagopilone in 30-minute infusions. Group B received sagopilone in 3-hour infusions.

The maximum reported toxicity level for group A was of grade 4, including peripheral sensory neuropathy (nerve damage; 8% of patients with grade 3-4).
The maximum toxicity level reported for group B was also of grade 4, including peripheral sensory neuropathy (21% of grade 3-4), arthritis (8%), and pain in the extremities (8%).

The median overall survival for groups A and B were 7.8 and 6.9 months, respectively.

This study was supported by Bayer Schering Pharma, makers of sagopilone.

Correspondence: Dr. G. Rustin; email:

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