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Brain Cancer treatment details. Biologic therapy. Chemotherapy. Copenhagen University Hospital, Copenhagen, Denmark

Survival: 6.9 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: Denmark
City/State/Province: Copenhagen
Hospital: Copenhagen University Hospital
Journal: Link
Date: 5/2010

This study involved 43 patients with recurrent primary glioblastoma multiforme. The median age of the group was 54 years and 58% were male.

Patients were treated with the biologic therapies bevacizumab (an antibody that blocks a protein involved in cancer cell growth) and cetuximab (a monoclonal antibody that targets cancer cells to be killed by the immune system), as well as the chemotherapy agent irinotecan.

There was one reported treatment-related death due to heart attack. In addition, 14% of patients experienced grade 3-4 infection, 9% grade 3-4 thrombocytopenia, and 60% had grade 1-2 skin reactions.

The reported median overall survival was 6.9 months.

Correspondence: Dr. Hans Skovgaard Poulsen; email:

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