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Ovarian Cancer treatment details. Biologic therapy. Chemotherapy. Departments of Medical Oncology, Mayo, Rochester, MN, United States

Survival: 15.5 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Rochester, MN
Hospital: Departments of Medical Oncology, Mayo
Journal: Link
Date: 4/2011

This study involved 18 women with platinum refractory or resistant ovarian or peritoneal cancer. The median patient age was 66 years. All patients had previously been treated with platinum-based therapy.

Patients in this study were treated with the chemotherapy agent topotecan and the biologic therapy lapatinib, which is a tyrosine kinase inhibitor.

There was one death reported as a grade 5 adverse event, however, the reported cause was disease progression not due to treatment. Otherwise, grade 4 neutropenia (3 patients) and diarrhea (1), as well as grade 3 dehydration (2) was reported.

The reported median overall survival was 15.5 months.

This study was supported by GlaxoSmithKline, the makers of lapatinib (brand name Tykerb) and topotecan (brand name Hycamtin).

Correspondence: Dr. Paul Haluska; email:

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