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Ovarian Cancer treatment details. Biologic therapy. Chemotherapy. Departments of Medical Oncology, Mayo, Rochester, MN, United States



Survival: 15.5 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Rochester, MN
   
Hospital: Departments of Medical Oncology, Mayo
   
Journal: Link
   
Date: 4/2011

Description:
Patients:
This study involved 18 women with platinum refractory or resistant ovarian or peritoneal cancer. The median patient age was 66 years. All patients had previously been treated with platinum-based therapy.

Treatment:
Patients in this study were treated with the chemotherapy agent topotecan and the biologic therapy lapatinib, which is a tyrosine kinase inhibitor.

Toxicities:
There was one death reported as a grade 5 adverse event, however, the reported cause was disease progression not due to treatment. Otherwise, grade 4 neutropenia (3 patients) and diarrhea (1), as well as grade 3 dehydration (2) was reported.

Results:
The reported median overall survival was 15.5 months.

Support:
This study was supported by GlaxoSmithKline, the makers of lapatinib (brand name Tykerb) and topotecan (brand name Hycamtin).

Correspondence: Dr. Paul Haluska; email: haluska.paul@mayo.edu

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