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Brain Cancer treatment details. Biologic therapy. Chemotherapy. Duke University Medical Center, Durham, NC, United States



Survival: 5.8 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Durham, NC
   
Hospital: Duke University Medical Center
   
Journal: Link
   
Date: 5/2011

Description:
Patients:
This study involved 25 patients with recurrent glioblastoma, who had received prior bevacizumab treatment. The median age of the group was 52 years and 68% were male.

Treatment:
Patients were treated with the chemotherapy agents carboplatin and irinotecan, as well as the biologic therapy agent bevacizumab.

Toxicities:
The maximum toxicity level reported was grade 4, including neutropenia and thrombocytopenia. Grade 3 fatigue, hypertension, and anemia were also reported.

Results:
The median overall survival was 5.8 months.

Support:
This study was partially funded by Genetech, makers of bevacizumab.

Correspondence: Dr. David A. Reardon; email: reard003@mc.duke.edu

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