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Liver Cancer treatment details. Biologic therapy. Massachusetts General Hospital Cancer Center, Boston, MA, United States

Survival: 8.4 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: Boston, MA
Hospital: Massachusetts General Hospital Cancer Center
Journal: Link
Date: 4/2011

This study involved 28 patients with advanced hepatocellular carcinoma. The median patient age was 65 years (range of 33-81) and 64% were male.

Patients were treated with the biologic therapy agent everolimus, an mTOR inhibitor that interferes with cancer cell and tumor growth.

Grade 4 anemia and hypoxia (oxygen deprivation) were reported. Grade 3 lymphopenia and decreased liver enzymes were also reported.

The median progression-free survival was 3.8 months and median overall survival was 8.4 months.

This study was funded by Novartis, makers of Afinitor (everolimus).

Correspondence: Dr. Andrew X. Zhu; email:

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