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Melanoma treatment details. Biologic therapy. Peking University Cancer Hospital, Beijing, China



Survival: 14.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: China
   
City/State/Province: Beijing
   
Hospital: Peking University Cancer Hospital
   
Journal: Link
   
Date: 6/2011

Description:
Patients:
This study involved 43 patients with metastatic melanoma. Patients had a median age of 57 years and 46.5% were male.

Treatment:
Patients were treated with the biologic therapy called imatinib mesylate, which is a tyrosine kinase inhibitor.

Toxicities:
The maximum toxicity reported was grade 4, including 1 case each of neutropenia and psychiatric symptoms and 2 cases of increased liver enzymes (AST/ALT). Grade 3 fatigue, anorexia, nausea, vomiting, and rash were also reported.

Results:
The median progression-free survival and median overall survival was 3.5 and 14.0 months, respectively.

Support:
This study was partially supported by Novartis Oncology in China.

Correspondence: Dr. Jun Guo; email: guoj307@126.com

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