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Ovarian Cancer treatment details. Chemotherapy. Instituto Valenciano de OncologıŽa, Valencia, Spain



Survival: 23.0 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: Spain
   
City/State/Province: Valencia
   
Hospital: Instituto Valenciano de OncologıŽa
   
Journal: Link
   
Date: 1/2011

Description:
Patients:
This study involved ovarian cancer patients with partially platinum-sensitive relapse after previous platinum-based therapy. Patients were divided into two separate treatment groups. Group A consisted of 91 patients with a median age of 56 years. Group B had 123 patients with a median age of 57 years.

Treatment:
Group A was treated with the chemotherapy agent pegylated liposomal doxorubicin (PLD). Group B was treated with the chemotherapy agents PLD and trabectedin.

Toxicities:
Maximum toxicity grade was 4 for both treatment groups. In group A, toxicities included 9 cases of grade 4 neutropenia and 17 cases of grade 3 hand-foot syndrome. Group B reported 39 cases of grade 4 neutropenia and 9 cases of grade 4 thrombocytopenia.

Results:
The reported median overall survival was 17.1 months for group A and 23.0 months for group B.

Support:
This study was supported by Johnson & Johnson, the makers of trabectedin.

Correspondence: Dr A. Poveda; email: apoveda@fivo.org

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