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Ovarian Cancer treatment details. Chemotherapy. Instituto Valenciano de OncologıŽa, Valencia, Spain

Survival: 23.0 months
Toxicity Grade: 4
Treatments: Chemotherapy
Country: Spain
City/State/Province: Valencia
Hospital: Instituto Valenciano de OncologıŽa
Journal: Link
Date: 1/2011

This study involved ovarian cancer patients with partially platinum-sensitive relapse after previous platinum-based therapy. Patients were divided into two separate treatment groups. Group A consisted of 91 patients with a median age of 56 years. Group B had 123 patients with a median age of 57 years.

Group A was treated with the chemotherapy agent pegylated liposomal doxorubicin (PLD). Group B was treated with the chemotherapy agents PLD and trabectedin.

Maximum toxicity grade was 4 for both treatment groups. In group A, toxicities included 9 cases of grade 4 neutropenia and 17 cases of grade 3 hand-foot syndrome. Group B reported 39 cases of grade 4 neutropenia and 9 cases of grade 4 thrombocytopenia.

The reported median overall survival was 17.1 months for group A and 23.0 months for group B.

This study was supported by Johnson & Johnson, the makers of trabectedin.

Correspondence: Dr A. Poveda; email:

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