Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results
Cancer
 

Click here to go back to your search results.

Lung Cancer treatment details. Biologic therapy. MD Anderson Cancer Center, Houston, TX, United States



Survival: 9.3 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Houston, TX
   
Hospital: MD Anderson Cancer Center
   
Journal: Link
   
Date: 5/2011

Description:
Patients:
This study involved patients with advanced non-small cell lung cancer (NSCLC) who were divided into 2 separate treatment groups. Group A consisted of 317 patients with a median age of 65 years, 54% of whom were male. Group B had 319 patients with a median age of 64.8 years and 54% male.

Treatment:
Patients in group A were treated with the biologic therapy agent erlotinib, a small molecule inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, which is involved in cell growth and survival.

Patients in group B were treated with erlotinib and the biologic therapy agent bevacizumab.

Toxicity:
There were 14 treatment-related deaths reported for group A, the causes of which were pneumonia, pulmonary embolism, and dyspnea (shortness of breath). Also reported was grade 3 blood clot and grade 3-4 hypertension.

For group B, there were 20 treatment-related deaths due to pneumonia, pulmonary embolism, dyspnea (shortness of breath), and bleeding. Also reported was grade 3 blood clot and grade 3-4 hypertension.

Results:
The median overall survival for groups A and B were 9.2 and 9.3 months, respectively.

Support:
This study was supported by Genentech, makers of erlotinib (brand name Tarceva) and bevacizumab (brand name Avastin).

Correspondence: Dr. Roy Herbst; email: roy.herbst@yale.edu

E-mail to a Friend Email Physician More Information