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Prostate Cancer treatment details. Chemotherapy. Roswell Park Cancer Institute, Buffalo, NY, United States



Survival: 17.2 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Buffalo, NY
   
Hospital: Roswell Park Cancer Institute
   
Journal: Link
   
Date: 5/2010

Description:
Patients:
This study involved patients with castration-refractory prostate cancer. Patients were divided into 2 separate treatment groups. Group A included 33 men with a median age of 68 years. Group B consisted of 38 men with a median age of 67 years.

Treatment:
Group A was treated with the chemotherapy agent docetaxel and the biologic therapy agent ASA404 (also known as Vadimezan), which is targeted to and disrupts the blood vessels in the tumor.

Group B was treated with docetaxel only.

Toxicity:
There were 2 treatment-related deaths in group A due to heart attack and neutropenic sepsis (infection). Also reported were grade 4 neutropenia and grade 3 gastrointestinal disorders and cardiac disorders.

In group B, there was 1 treatment-related death due to a cerebrovascular event (stroke). Also reported were grade 4 neutropenia and grade 3 gastrointestinal disorders.

Results:
The median overall survival for groups A and B were 17.0 and 17.2 months, respectively.

Support:
This study was supported by Antisoma Research, the makers of ASA404.

Correspondence: Dr. Roberto Pili; email: roberto.pili@roswellpark.org

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