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Brain Cancer treatment details. Biologic therapy. Chemotherapy. Radiation. Duke University Medical Center, Durham, NC, United States



Survival: 21.2 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
Radiation
   
Drugs:
Country: United States
   
City/State/Province: Durham, NC
   
Hospital: Duke University Medical Center
   
Journal: Link
   
Date: 6/2011

Description:
Patients:
This phase II study involved 75 patients with newly diagnosed glioblastoma. Of the patients, 45 were male and the median age was 55.6 years.

Treatment:
Patients were treated with radiation therapy, the biologic therapy agent bevacizumab (an antibody that blocks a protein involved in cancer cell growth), and the chemotherapy agents temozolomide and irinotecan.

Toxicities:
Treatment-related deaths due to sepsis and pulmonary embolism were reported. Grade 4 thrombocytopenia and neutropenia were also reported.

Results:
The reported median overall survival was 21.2 months.

Support:
This study was partially supported by Genentech Pharmaceuticals.

Correspondence: Dr. James J. Vredenburgh; email: vrede001@mc.duke.edu

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