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Melanoma treatment details. Chemotherapy. University of Nottingham, Nottingham, United Kingdom

Survival: 9.1 months
Toxicity Grade: 5
Treatments: Chemotherapy
Country: United Kingdom
City/State/Province: Nottingham
Hospital: University of Nottingham
Journal: Link
Date: 5/2011

This phase III study involved stage IV melanoma patients who were divided into two separate treatment groups. Group A included 429 patients, 64% of whom were over the age of 65 years and 58% were male. Group B had 430 patients, 61% of whom were over the age of 65 years and 59% were male.

Patients in group A were treated with the chemotherapy agent temozolomide. Patients in group B were given the chemotherapy agent dacarbazine.

Deaths due to adverse events were reported for both groups (6 in group A and 7 in group B), but it was mentioned that they were not attributed to treatment. Grade 3-4 neutropenia, lymphopenia, thrombocytopenia, fatigue, and vomiting were also reported for both groups.

The reported median overall survival for groups A and B was 9.1 and 9.4 months, respectively.

This study was supported by the pharmaceutical company Schering Plough.

Correspondence: Dr. Poulam M. Patel; email:

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