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Brain Cancer treatment details. Biologic therapy. Radiation. University of California, San Francisco, School of Medicine, San Francisco, California, United States

Survival: 8.8 months
Toxicity Grade: 3
Treatments: Biologic therapy
Country: United States
City/State/Province: San Francisco, California
Hospital: University of California, San Francisco, School of Medicine
Journal: Link
Date: 12/2002

Patients: This Phase II study involved 26 patients with recurrent malignant gliomas. Fourteen had glioblastoma multiforme or gliosarcoma (i.e. grade IV), and there were 12 patients with grade III tumors (8 anaplastic astrocytomas, 1 oligodendroglioma, and 3 mixed malignant gliomas).

Treatment: The treatment consisted of high central dose Gamma Knife radiosurgery and the drug marimastat.

Toxicity: Toxicity included musculoskeletal (grade 1-3), hematologic (grade 1-2), and nausea/vomiting (grade 1-2).

Results: For the grade IV patients, the median survival was 38 weeks (8.8 months).

Correspondence: David A. Larson, MD, PhD

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