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Prostate Cancer treatment details. Chemotherapy. University of Siena, Siena, Italy



Survival: 27.3 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: Italy
   
City/State/Province: Siena
   
Hospital: University of Siena
   
Journal: Link
   
Date: 2/2011

Description:
Patients:
This study involved male patients with advanced castration-resistant prostate cancer that were divided into two separate treatment groups. Group A included 37 patients with a median age of 72 years. Group B consisted of 35 patients with a median age of 70 years.

Treatments:
Patients in group A were treated with the chemotherapy agents docetaxel and epirubicin. Group B was given the chemotherapy agent docetaxel and the hormone prednisone.

Toxicities:
The maximum adverse reaction level for each group was grade 4. Patients in group A reported grade 3-4 neutropenia, anemia, and nail changes. Group B reported grade 3-4 neutropenia and nausea/vomiting.

Results:
The reported median overall survival reported for groups A and B was 27.3 and 19.8 months, respectively.

Correspondence: Dr. R Petrioli; email: r.petrioli@ao-siena.toscana.it

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