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Colon Cancer treatment details. Biologic therapy. Chemotherapy. Aichi Cancer Center Hospital, Nagoya, Japan



Survival: 10.8 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Japan
   
City/State/Province: Nagoya
   
Hospital: Aichi Cancer Center Hospital
   
Journal: Link
   
Date: 12/2010

Description:
Patients:
This phase II study involved 30 metastatic colorectal cancer patients (mCRC) who were resistant to previous irinotecan, oxaliplatin, and fluoropyrimidine treatment. The median patient age was 61 years and 19 of the patients were male.

Treatment:
Patients were treated with the chemotherapy agent irinotecan and the biologic therapy agent cetuximab, which is a monoclonal antibody that targets cancer cells to be killed by the immune system.

Toxicities:
There was 1 treatment-related death due to pneumonia reported in this study. Grade 3/4 neutropenia, diarrhea, and skin toxicities were also reported.

Results:
The reported median overall survival was 10.8 months.

Correspondence: Dr. Kohei Shitara; email: Kouheis0824@yahoo.co.jp

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