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Brain Cancer treatment details. University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States



Survival: 8.1 months
   
Toxicity Grade: 4
   
Treatments:
   
Drugs:
Country: United States
   
City/State/Province: Houston, Texas
   
Hospital: University of Texas M. D. Anderson Cancer Center
   
Journal: Link
   
Date: 6/2003

Description:
Patients: This Phase II study involved 88 patients with recurrent and progressive malignant gliomas (40 with glioblastoma multiforme (one had a gliosarcoma), 28 with anaplastic astrocytoma, 13 with anaplastic oligodendroglioma, one with iligodendroglioma, and six with mixed anaplastic glioma).

Treatment: Treatment consisted of: the chemotherapy drug temozolomide and the biological agent 13-cis-retinoic acid (a retinoid).

Toxicity: Grade 4 toxicities included: granulocytopenia, hypercholesterolemia, leucopenia, and thrombocytopenia.

Results: The median overall survival for the glioblastoma multiforme patients was 35 weeks (8.1 months).

Correspondence: Kurt A. Jaeckle, MD

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