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Colon Cancer treatment details. Biologic therapy. Chemotherapy. Austin Health, Victoria, Australia



Survival: 16.4 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Australia
   
City/State/Province: Victoria
   
Hospital: Austin Health
   
Journal: Link
   
Date: 7/2010

Description:
Patients:
This study involved patients with metastatic colorectal cancer who were divided into 3 separate treatment groups. Group A consisted of 156 patients with a median age of 69 years and 63% male. Group B had 157 patients with a median age of 67 years and 65% male. Group C had 158 patients with a median age of 67 years and 60% male.

Treatment:
Group A was treated with the chemotherapy agent capecitabine. Group B received capecitabine and the biologic therapy agent bevacizumab. Group C was treated with capecitabine, bevacizumab, and the chemotherapy agent mitomycin.

Toxicities:
One treatment-related death due to sepsis was reported for group A. Grade 3/4 diarrhea and hand-foot syndrome was also reported for this group.

There were 7 treatment-related deaths reported for group B. Causes included hemorrhage, myocarditis (inflammation of the heart), bowel perforation, and sepsis.

Three treatment-related deaths due to hemorrhage, pulmonary embolism, and neutropenic colitis were reported for group C.

Results:
The median overall survival was 18.9 months for groups A and B and 16.4 months for group C.

Support:
This study was partially supported by Roche pharmaceuticals.

Correspondence: Dr. Niall Tebbutt; email: niall.tebbutt@ludwig.edu.au

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