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Liver Cancer treatment details. Biologic therapy. Chemotherapy. Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, United States



Survival: 9.8 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Philadelphia, PA
   
Hospital: Abramson Cancer Center, University of Pennsylvania
   
Journal: Link
   
Date: 7/2011

Description:
Patients:
This phase II study involved 40 patients with advanced hepatocellular carcinoma who had not received prior chemotherapy. The median patient age was 56 years and 80% of the patients were male.

Treatment:
Patients were treated with the biologic therapy agent bevacizumab and the chemotherapy agents capecitabine and oxaliplatin.

Toxicities:
There was 1 treatment-related death due to gastric perforation and sepsis (blood infection). Grade 3/4 peripheral neurotoxicity, fatigue, and diarrhea were also reported.

Results:
The median progression-free and overall survival rates were 6.8 and 9.8 months, respectively.

Support:
This study was supported by Genentech, makers of bevacizumab (brand name: Avastin).

Correspondence: Dr. Weijing Sun; email: weijing.sun@uphs.upenn.edu

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