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Lung Cancer treatment details. Biologic therapy. Sarah Cannon Research Institute, Nashville, TN, United States

Survival: 7.6 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: Nashville, TN
Hospital: Sarah Cannon Research Institute
Journal: Link
Date: 6/2011

This study involved previously treated advanced non-small cell lung cancer patients who were divided into 2 treatment groups. Group A consisted of 111 patients with a median age of 65 years and 56% were male. Group B had 55 patients with a median age of 65 years and 47% male.

Group A was treated with the biologic therapy agents sorafenib and erlotinib. Group B was given erlotinib and a placebo.

The maximum toxicity reported for group A was of grade 4, including grade 3/4 diarrhea (15% of patients), fatigue (14%), and anorexia (10%).

There was one treatment-related death due to diarrhea in group B. Grade 3/4 rash (13%) and anorexia (9%) were also reported.

The median overall survival for groups A and B was 7.62 and 7.23 months, respectively.

This study was supported by the pharmaceutical companies Bayer HealthCare, Onyx, and OSI.

Correspondence: David R. Spigel; email:

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