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Prostate Cancer treatment details. Biologic therapy. Norris Comprehensive Cancer Center, Los Angeles, CA, United States



Survival: 11.6 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Los Angeles, CA
   
Hospital: Norris Comprehensive Cancer Center
   
Journal: Link
   
Date: 6/2010

Description:
Patients:
This phase II study involved 53 men with castration-resistant prostate cancer who had received previous chemotherapy. The median patient age was 71 years.

Treatment:
Patients were treated with the biologic therapy agent siltuximab, which is a monoclonal antibody that recognizes IL-6.

Toxicities:
The most severe adverse effect was grade 4 disseminated intravascular coagulation (blood clotting). Grade 3/4 pain and neuropathy was also reported.

Results:
The median overall survival was 11.6 months.

Support:
This study was partially supported by Centocor, Inc., makers of siltuximab.

Correspondence: Dr. Tanya B. Dorff; email: dorff@usc.edu

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