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Colon Cancer treatment details. Biologic therapy. University of Chicago, Chicago, IL, United States



Survival: 5.1 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Chicago, IL
   
Hospital: University of Chicago
   
Journal: Link
   
Date: 5/2011

Description:
Patients:
This phase II study involved 19 patients with previously treated metastatic colorectal cancer. The median patient age was 64 years and 58% were male.

Treatment:
Patients were treated with the biologic therapy agent called dasatinib, which is an inhibitor of protein-tyrosine kinases, and therefore interferes with internal signals in cancer cells.

Toxicities:
Treatment-related death due to heart attack was reported for this study. Grade 3 fatigue, anemia, anorexia, and nausea/vomiting were also reported.

Results:
The reported median overall survival was 5.1 months.

Correspondence: Dr. Hedy L. Kindler; email: hkindler@medicine.bsd.uchicago.edu

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